747 Objective To explore how the scale of a project affects both the total costs and average costs of HIV prevention in India. Methods Economic cost data and measures of scale (coverage and service volume indicators for number of cases of sexually transmitted infections (STIs) referred, number of STIs treated, condoms distributed and contacts made with target groups) were collected from 17 interventions run by nongovernmental organizations aimed at commercial sex workers in southern India. Non- parametric methods and regression analyses were used to look at the relationship between total costs, unit costs and scale. Findings Coverage varied from 250 to 2008 sex workers. Annual costs ranged from US$ 11 274 to US$ 52 793. The median cost per sex worker reached was US$ 19.21 (range = US$ 10.00?51.00). The scale variables explain more than 50% of the variation in unit costs for all of the unit cost measures except cost per contact. Total costs and unit costs have non-linear relationships to scale. Conclusion Average costs vary with the scale of the project. Estimates of resource requirements based on a constant average cost could underestimate or overestimate total costs. The results highlight the importance of improving scale-speci?c cost information for planning. Keywords HIV infections/prevention and control/economics; Prostitution; Sexually transmitted diseases/therapy; Contact tracing/ economics; Condoms/economics; Costs and cost analysis; India ( source: MeSH, NLM ). Mots clés Infection à VIH/prévention et contrôle/économie; Prostitution; Maladies sexuellement transmissibles/thérapeutique; Recherche sujet contact/économie; Condom/économie; Coût et analyse coût; Inde ( source: MeSH, INSERM ). Palabras clave Infecciones por VIH/prevención y control/economía; Prostitución Enfermedades sexualmente transmisibles/terapia; Trazado de contacto/economía; Condones/economía; Costos y análisis de costo; India ( fuente: DeCS, BIREME ). Bulletin of the World Health Organization 2005;83:747-755. Voir page 754 le résumé en français. En la página 754 ?gura un resumen en español. Does scale matter? The costs of HIV-prevention interventions for commercial sex workers in India Lorna Guinness, 1 Lilani Kumaranayake, 1 Bhuvaneswari Rajaraman, 2 Girija Sankaranarayanan, 3 Gangadhar Vannela, 4 P. Raghupathi , 5 & Alex George 4 1 Department of Public Health and Policy, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, England. Correspondence should be sent to Dr Guinness at this address (email:lorna.guinness@lshtm.ac.uk). 2 Indian Institute of Technology (Madras), India. 3 Emory University, Atlanta, GA, USA. 4 Centre for Health and Social Sector Studies, Hyderabad, Andhra Pradesh, India. 5 University of Hyderabad, Andhra Pradesh, India. Ref. No. 04-017459 ( Submitted: 13 August 2004 ? Final revised version received: 10 December 2004 ? Accepted: 10 January 2005 ) .754 Introduction UNAIDS has highlighted the urgent need to scale-up preven - tion programmes as global funding for treatment and care for people living with AIDS increases. The understanding of the resource requirements needed to expand these activities has improved at the global level as a result of costings made by UNAIDS and the Commission on Macroeconomics and Health (1?3). However, these estimates still lack standardized datasets on cost structures for particular interventions at dif - ferent scales of activity and in different environments. Improv - ing the understanding of resource requirements is critical to identifying the cost implications of efforts to expand ongoing prevention services included in the work of the Global Fund to Fight AIDS, Tuberculosis and Malaria; the World Bank?s Multi-Country HIV/AIDS Program for Africa; and the World Health Organization?s 3 by 5 initiative. Economic theory hypothesizes that as scale increases, total costs increase at a changing rate, giving rise to the classic U-shaped average cost curve. This curve results from certain inputs varying with the level of output (such as the cost of condoms or drugs) and, in the short run, other costs remain - ing ?xed (such as overheads and building costs). As the scale increases, ?xed costs are shared over an increasing number of outputs until they reach the limit of their capacity. This sharing of ?xed costs leads to non-linearities in the relationship be - tween total costs and scale. Evidence from other health services supports the theory of non-linearities and suggests that costs vary with scale as well as with a number of other contextual, organizational and intervention-speci?c factors (4?12). In India, where an estimated 5.1 million people are liv - ing with HIV or AIDS (13), the National AIDS Control Pro - gramme, under the direction of the National AIDS Control 748 Bulletin of the World Health Organization | October 2005, 83 (10) Research HIV prevention in India Lorna Guinness et al. Organization, has contracted with nongovernmental organiza - tions (NGOs) to target HIV prevention towards higher-risk groups (14?17, and National AIDS Control Organization, unpublished guidelines, 2000). Data on the costs of these ini - tiatives are scarce (18, and D Wilson. Review of the Healthy Highways Project, unpublished report, 1999; V Gonzales et al. Midterm evaluation of West Bengal Sexual Health Project, unpublished report, 1999); there is little information to draw on from elsewhere (4, 19, 20); and there is limited evidence on how total costs change as activities expand (21). In analysing the costs of 17 HIV-prevention interven - tions targeted at commercial sex workers in southern India, this paper explores how scale affects site-speci?c total costs and average costs of HIV prevention. It is the ?rst paper to present cost data collected from multiple sites for a single HIV-preven - tion intervention. The analysis addresses previous problems of methodological and de?nitional differences and variations in input valuation, which researchers often face when using cost information from different studies (4, 20, 22), by using a stan - dardized method across the sites. It is therefore able to explore how costs vary with scale. Methods Sample selection A case-study approach was used to enable in-depth insights as well as collection of full economic costs. Seventeen NGOs were selected from the 259 targeted interventions identi?ed in a census survey of interventions in Andhra Pradesh and Tamil Nadu (Table 1, available only on the web at http://www.who. int/bulletin). Both states had contracted with NGOs on a large scale (i.e., for more than 50 interventions). Interventions were purposively sampled according to their capacity, the funding agency, their geographical location, experience in implement - ing HIV interventions and willingness to participate. Only interventions aimed at commercial sex workers were selected in order to control for differences in intervention activities, epidemiology and target populations. Similarities in interven - tion design were further ensured by the National AIDS Control Organization?s prescription of key components: information and education on behavioural change, condom distribution, peer education, management of sexually transmitted infections (STIs), and creating an enabling environment for the inter - vention (23, 24, and National AIDS Control Organization, unpublished guidelines, 2000). Data collection Economic data on providers? costs were collected for the ? - nancial year 2001?2002; data included information on costs incurred at the intervention-level and funding-agency level. Economic costs include all inputs involved in the intervention and value them at their opportunity cost (including inputs that are donated or subsidized). This provides a standardized method for data collection, enabling valid cost comparisons across the interventions. The ingredients approach to costing was used as far as possible (see, for example, (5)). Measuring scale Scale is de?ned from an economic perspective ? that is, it is the extent or level of activity at which an intervention is op - erating (25, 26). Coverage, which is measured by the number of people reached, re?ects scale as de?ned by national policy. Another six indicators re?ect different aspects of the volume of services delivered: number of commercial sex workers referred for STI treatment, number of STIs treated, number of condoms distributed, number of ?rst contacts made with members of the target group, total number of contacts made with mem - bers of the target group and total number of contacts with the members of the community. All scale measures were obtained from NGO?s routine monitoring systems. Input identi?cation Inputs were identi?ed by reviewing project documentation, by interviewing project personnel and by ascertaining local market prices (Appendix 1, available only on the web at http://www. who.int/bulletin). They were classi?ed as ?xed or variable, ac - cording to standard economic de?nitions (5). Where quantities were not available, expenditures were used to represent input levels. Because methods of STI management varied, this was considered an input category in itself. Funding agency-level inputs were allocated to the interventions using direct alloca - tion methods (27). Cost valuation All costs were valued at local market prices. Peer educators? time and costs were ascertained through a simple bidding game that generated values which were then validated in interviews with outreach staff. Condoms distributed free of charge were valued at the price of the lowest cost alternative in the market ? that is, a subsidized socially marketed condom. Because there were Table 3. Characteristics of 17 HIV-prevention interventions run by selected nongovernmental organizations (NGOs) and targeted at sex workers, Tamil Nadu and Andhra Pradesh, India. Values are numbers (%), unless otherwise indicated Characteristics of the interventions a Distribution Intervention design STI treatment Referral 15 (88) NGO?s own clinic 2 (12) Context Tamil Nadu 8 (47) Andhra Pradesh 9 (53) Median % (range) literacy 73 (59?85) Median (range) length of time project 6 (3?13) under way (years) Capacity Certi?ed to receive foreign funds No certi?cate 3 (17.6) Certi?ed 14 (82.4) Median No. (range) of staff working 39.3 (4.9?95.3) on HIV ( n = 16) Median (range) annual expenditure 51.6 (5.3?1 088.3) (US$ ?000) ( n = 14) Financing Funding agency A 9 (52.9) B 2 (11.8) C 2 (11.8) D 4 (23.5) Median (range) HIV project budget (US$ ?000) ( n = 15) 15.5 (4.8?27.2) a n = 17 unless otherwise speci?ed. 749 Research Lorna Guinness et al. HIV prevention in India no data on revenues, the net cost of condom sales (i.e., the cost of condom procurement minus revenue from sales) was assumed to be 0. Annualized economic costs were calculated using a standard discount rate of 3% (see, for example, (27)). Capital items were assumed to have a life of between 3 and 10 years, depending on the item. All costs were converted to constant 2002?03 Indian rupees, using the GDP (Gross Domestic Product) de?ator, and then converted to US dollars (US$ 1.00 = 42 rupees) (28). Analysis Scale, total costs, cost structures and unit costs (total costs divided by a scale variable) were compared across the interven - tions. Due to the small sample size, non-parametric methods were used to look at the relationship between scale and the two cost variables: total costs and unit costs. The cost variables were regressed on scale, comparing linear and quadratic equa - tion forms. Non-parametric methods were also used to look at whether scale, total costs and unit costs are affected by fac - tors including the state where the intervention took place, the funding agency, the method of STI management, district literacy levels, length of time the project has been under way, the intervention?s budget and the NGO?s capacity. Two tests were used: the median test for categorical explanatory variables (reported as Pearson?s ?²) and Spearman?s rank?order correla - tion coef?cient ( r s ) test for independence of samples for the continuous explanatory variables (see, for example, (29)). The null hypothesis for each test was that there was no relationship between scale variables or cost variables and the explanatory variable. Sensitivity analysis Due to the retrospective nature of the study, several constraints were faced in data collection: some data were missing; there were inaccuracies in the data; and sometimes prices had to be used in place of cost. One-way sensitivity analysis was used to account for these limitations by manually changing values in the costing spreadsheets (Table 2, available at http://www.who. int/bulletin) and generating ranges of total costs and unit costs for each intervention. The non-parametric tests and regressions were then run again to explore whether relationships still held when extreme values were used. Findings NGO characteristics Characteristics of the selected NGOs are described in Table 3. Of the sample, 8 were in Tamil Nadu and 9 were in Andhra Pradesh. Four different funding agencies were represented in the sample. District literacy rates ranged from 60% to 85%. The NGOs? total annual expenditures ranged from US$ 5324 to US$ 1.1 million, with the proportion of staff working on HIV representing between 5% and 95% of all staff. Three NGOs were not certi?ed to receive foreign funds. The length of time the intervention had been under way varied from 3 to 13 years. Two of the interventions provided STI services at their own clinics; 12 NGOs referred people for treatment but subsidized their treatment; and 3 made referrals only. Total costs and cost pro?les Total costs and their breakdown are described in Table 4. The median total cost was US$ 19 958 (range = US$ 11 274?52 793). Table 4. Total costs and cost pro?les of 17 HIV-prevention interventions run by selected nongovernmental organizations (NGOs) and targeted at sex workers, Tamil Nadu and Andhra Pradesh, India a Cost category Costs (US$ ?000) b Median Minimum Maximum Fixed personnel 3.63 (15.7) c 1.08 (6.5) 8.27 (22.6) Training 0.12 (0.6) 0 1.70 (3.2) Monitoring 0.55 (1.9) 0.03 (0.2) 0.92 (3.6) Building and of?ce costs 2.57 (12.7) 0.46 (3.6) 5.29 (26.1) Vehicles 0.07 (0.4) 0 (0) 2.37 (10.4) Total ?xed 6.80 (34.1) 1.71 (13.5) 16.10 (40.6) Variable personnel 4.62 (19.7) 1.28 (10.4) 6.49 (28.9) Peer educators 2.16 (9.9) 0.34 (1.2) 12.83 (34.9) Information, education and communication materials 0.38 (1.3) 0.01 (0.1) 2.21 (12.8) STI treatment d 0.71 (3.3) 0 (0) 2.33 (10.7) Condoms 0.85 (3.8) 0.01 (0.1) 7.37 (18.8) Meetings 0.72 (3.5) 0.08 (0.4) 2.32 (8.8) Transport 1.36 (4.6) 0.15 (1.2) 2.45 (9.3) Other 0.40 (1.3) 0 (0) 1.62 (5.3) Total variable 10.88 (53.2) 4.48 (39.7) 34.19 (70.7) Total NGO 17.04 (88.5) 6.78 (60.1) 50.28 (95.3) Agency 2.51 (11.5) 1.53 (4.7) 4.50 (39.9) Total 19.96 (100.0) 11.27 (100.0) 52.79 (100.0) a The minimum number of commercial sex workers reached by an intervention was 250; the median was 1047; the maximum was 2008. b Costs are in 2002?03 prices. c Values in parentheses are the median, minimum and maximum values for the percentages of total costs in each cost category. d STI = sexually transmitted infection. 750 Bulletin of the World Health Organization | October 2005, 83 (10) Research HIV prevention in India Lorna Guinness et al. Table 5. Coverage, volume per commercial sex worker reached and non-parametric tests for factors in?uencing scale variables for the 17 HIV-prevention interventions run by selected nongovernmental organizations (NGOs) and targeted at commercial sex workers, Tamil Nadu and Andhra Pradesh, India Intervention characteristic Unit a Sample Relationship with size coverage (Spearman?s r s ) b Sex workers reached by the intervention ( n = 17) 1 047 (250?2008) 17 1.000 People referred to health-care providers by the project 0.37 d (0.09?2.20) 17 0.3235 for consultation on STI c ( n = 17) People treated for STIs by the project or as a result 0.32 d (0.11?0.71) 14 0.6205 e of the project?s referrals or subsidies ( n = 15) Condoms distributed for free and through NGO sales ( n = 17) 101.10 d (11.41?1001) 17 0.2304 First-time project contacts with members of the target group ( n = 14) 0.71 d (0.20?1.49) 15 0.4500 f Contacts with members of the target group (?rst and repeat) ( n = 11) 3.43 d (1.68?9.22) 11 0.2091 Contacts with members of the target group plus contacts 3.83 d (2.30?10.19) 11 0.3455 with the broader community (?rst and repeat) ( n = 11) Budget 17 0.7527 e Project age 17 0.2034 NGO expenditure 14 0.0549 HIV staff share 16 0.1321 Literacy 17 - 0.5817 e Pearson?s ? ² State 17 1.8862 Funding agency 17 4.9554 e Certi?ed to receive foreign funds 17 0.1365 STI service provision 17 0.0048 a Values in this column are median (range). b Values in this column measure the strength of the relationship between the variables: the closer r s is to + /-1.0, the stronger the relationship between the two continuous variables; the higher the absolute value of ?², the stronger the correlation between the continuous and the categorical variables. c STI = sexually transmitted infection. d Value is per person reached. e P < 0.05. f P < 0.01 The levels at which costs are incurred and the cost pro?les also vary. The median value of the proportion of costs incurred at the agency level (11.5%) hides a wide variation across NGOs, from 5% to 39.9%. Variable costs range from 40% to 71% of total costs, with a median value of 53.2%. Personnel (staff time) costs are the largest portion of variable costs and range from 10% to 29%. On average the cost of peer education is the next largest part of variable costs (9.9%). The cost of peer educators also has the largest variation in relative contribution to the interven - tion. Although peer educators could be a substitute for or a complement to staff, no relationship, on average, is observed between the cost of peer educators and staff costs ( r s = 0.1368; probability t < 1 = 0.6764). The cost of STI treatment appears to var y with the different methods of management; the proportion of costs attributable to STI treatment was highest at the two sites that provided clinic services. This relationship is not signi?cant (Pearson?s ?² = 1.6410; probability t < 1 = 0.2) indicating that other factors in?uence this part of the cost ratio, e.g. the share of peer-educator costs is low where the share of STI treatment costs is high. There is a wide variation in the relative costs of condoms, from 0.1% to 19% of total costs. Pro?les of ?xed costs also show variability, ranging from 13.5% to 41% of total costs. Personnel and building costs (including rent and maintenance and all expenses associated with running an of?ce) are the most important ?xed costs, with median values of 16% and 12%, respectively. Although training costs appear to be low, the majority of these costs are incurred at the agency level, comprising between 6% and 28% of agency costs. Scale of the interventions In terms of coverage, interventions reached from 250 to 2008 commercial sex workers (Table 5), and non-parametric tests show that there are signi?cant relationships between coverage and funding agency, budget (positive) and literacy rate (nega - tive). Because coverage levels vary across the interventions, comparisons of service volume were made by ?rst dividing the volume descriptors by coverage, thus revealing large variations in service volume. Although a relationship between volume and coverage was expected, no signi?cant relationship was observed, except in the case of number of STIs treated. Average costs of the interventions Unit costs of the intervention are described in Table 6. The cost per person reached ranges from US$ 9.86 to US$ 50.70. The median value is US$ 19.20. Variation is also evident in the cost per unit of volume of services, e.g. the median cost per STI treated is US$ 62.50 (range = US$ 13.90?141.20) and the cost per ?rst contact with the target group is US$ 26.30 (range = US$ 13.88?59.80). 751 Research Lorna Guinness et al. HIV prevention in India Analysis of cost variation Total cost had statistically signi?cant and positive relationships with both coverage and all but one of the indicators of volume (all contacts with the target group) (Table 6). Fig. 1 shows how total costs increase with coverage and suggests that total costs do not increase linearly. The quadratic model has a higher R ² (measure of ?goodness of ?t? of the regression) than the linear form, supporting the hypothesis. The quadratic relationship between total costs and scale also applies to the volume in - dicators except condoms distributed, all contacts with target groups and all contacts. The regressions imply that there is a positive linear relationship between condoms and total costs. However, neither the linear model nor the quadratic model is a good ?t for the relationships between the contact variables (F is not signi?cant and R ² < 0.1). The null hypothesis (that there is no relationship be - tween unit cost and measures of scale) can also be rejected. The results of the non-parametric tests of cost per unit of scale against the respective scale unit are all negative and, with the Table 6. Relationship between total costs, unit costs and scale for 17 HIV-prevention interventions run by selected nongovernmental organizations (NGOs) and targeted at commercial sex workers, Tamil Nadu and Andhra Pradesh, India Measure of scale Total costs a Unit costs (US$ ?000) b Median (range) Spearman?s rho ( r s ) Coverage ( n = 17) 0.7990 c 19.21 (9.86?50.70) - 0.5221 c Sexually transmitted infections referred ( n = 17) 0.4828 c 49.82 (16.47?167.48) - 0.8750 c Sexually transmitted infections treated ( n = 14) 0.5017 d 62.49 (13.91?141.19) - 0.7987 c Condoms distributed ( n = 17) 0.4804 d 0.22 (0.05?1.28) - 0.9216 c First contacts with target group ( n = 15) 0.4500 d 26.29 (13.88?59.81) - 0.7964 c All contacts with target group ( n = 11) 0.4273 4.97 (1.74?11.27) - 0.7182 c All contacts ( n = 11) 0.5545 d 4.68 (1.57?8.46) - 0.5000 Median total cost (range) in US$ ?000s 19.96 (11.27?52.79) a Values in this column measure the strength of the relationship between unit cost and the respective unit of scale: the closer r s is to + /-1.0, the stronger the relationship between the two continuous variables. b Values are constant 2002?03 prices. c P < 0.05. d P < 0.01 Fig. 1. Regression: a) Linear and b) quadratic forms of total costs against scale of HIV-prevention interventions targeted at commercial sex workers (CSWs). (V alues are for 2002?03 prices; additional statistical information is av ailable at the following URL: http://www .who .int/bulletin) WHO 05.7095% confidence interv als T otal annual cost 000s US$ Fitted v alues 50 Total annual cost (x 10 3 US$) 40 30 20 10 0 0 500 1000 1500 2000 No. of CSWs reached 50 Total annual cost (x 10 3 US$) 0 500 1000 1500 2000 No. of CSWs reached 40 30 20 10 a) b) exception of all contacts, statistically signi?cant (Table 6). The scale variables explain more than 70% of the variation in unit costs for all measures of unit costs except cost per sex worker reached and cost per contact. The in?uence of the fac - tors, described in Table 3, on unit costs was also tested using non-parametric methods (see Appendix 2 and Appendix 3, available only on the web at http://www.who.int/bulletin ). We could not reject the null hypothesis of no relationship except for a negative relationship between budget and the cost per condom distributed, a positive relationship between the length of time the project had been under way and the cost per sex worker referred for STI treatment or the cost per STI treated, a positive relationship between the price of ?eld workers and the cost per contact, and a positive relationship between the price of peer educators and the cost per STI referred. The regressions of unit costs against scale suggested non- linear relationships except in the case of all contacts (Fig. 2). In looking at the ?tted regression line of cost per sex worker reached against coverage, we observed a ?tted line resembling 752 Bulletin of the World Health Organization | October 2005, 83 (10) Research HIV prevention in India Lorna Guinness et al. a classic U-shaped average cost curve in which there is a cost- minimizing level of coverage in the range of 1000?1700 sex workers reached. The sensitivity analysis generated ranges for the total costs between 10% and 40% of the value in the original analysis. Similarly, the range of unit costs was between 10% and 43% of the original values. The best-?t regression models for cost per person reached (Fig. 3) and cost per measure of volume held when they were run again with these extreme values. Discussion The cost analysis of targeted HIV-prevention interventions pre - sented here explores how costs vary across similar interventions, with a particular focus on how costs vary according to the scale of the intervention. Differences were found in the scale, total costs, cost structures and average costs. Both total costs and Fig. 2. Fitted regression: a) Linear and b) quadratic forms of costs per unit of scale for the HIV-prevention interventions targeted at commercial sex workers (CSWs). (V alues are 2002?03 prices; additional statistical information is av ailable at the following URL: http://www .who .int/bulletin) WHO 05.7195% confidence interv als T otal annual cost 000s US$ Fitted v alues 50 Cost per CWS reached (x 10 3 US$) 40 30 20 10 0 0 500 1000 1500 2000 No. of CSWs reached 50 Cost per CWS reached (x 10 3 US$) 40 30 20 10 0 500 1000 1500 2000 No. of CSWs reached a) b) Fig. 3. Sensitivity analysis plots of quadratic relationship between coverage of commercial sex workers (CSWs) and a) total costs and b) cost per person reached. (Additional statistical information is av ailable at the following URL: http://www .who .int/bulletin) Maximum v alues of cost Median v alues of cost Minimum v alues of cost WHO 05.72 b) 80 Cost per CSW reached (x 10 3 US$) 0 500 1000 1500 2000 No. of CSWs reached 60 40 20 0 50 Total annual cost (x 10 3 US$) 0 500 1000 1500 2000 No. of CSWs reached a) 40 30 20 10 0 average costs were found to have signi?cant relationships with the scale variables. These relationships were not linear. Despite the large contribution of variable costs to the cost structure, average costs vary with scale: a point where average costs begin to rise is reached at relatively low levels of coverage. This analysis is limited by being retrospective and by its use of routine monitoring systems not speci?cally designed for cost analyses. In some cases, inputs and values to the project were estimated based on interviews rather than records. Out - puts were taken from routine monitoring systems, and these can be subject to errors. Financial data were used as a proxy for the economic costs of transport and monitoring owing to a lack of records. The small sample, compounded by the diversity in the organizations? characteristics, limits our ability to allow con?dent inference from the non-parametric and regression analyses. Therefore, interpretations of the results should be made with caution. In addition, it is not possible to determine 753 Research Lorna Guinness et al. HIV prevention in India the strength of the relationships of scale with the other dimen- sions because multivariate analysis would be required. In spite of these problems,the one-way sensitivity analysis showed the results to be quite robust. Although there may also be bias resulting from the necessary sampling criteria of ?agreement to participate?,the direction of this bias is ambiguous,i.e. those agreeing to participate are likely to be better at reporting and this may or may not imply that the sample has average costs that are consistently lower or higher. Variations in scale may arise from the length of time the intervention has been under way, the ?reachability? and size of the target group as well as the targets set by the contracting agent. Coverage varied according to the funding agency and the budget. Because annual budgets depend on achievements made during the previous year and, at the time of the study, there was limited information on the size of the target popula - tions,it is likely that coverage re?ects the ability to negotiate targets rather than the actual size of the population. This may also apply to differences in volume with respect to coverage: for one funding agency, STI targets and budgets were set according to the agreed coverage of targets. However, these measures also con?rm the degree of variation in technical ef?ciency (cost per unit of output) across apparently similar interventions. As with scale, total costs are likely to be driven by budgets and targets set by the organizations. Further analysis ?nds that of the factors shown in Table 3,only ?funding agency? had a signi?cant relationship with total cost (Pearson?s ? ² = 13.4321; probability t < 1 = 0.004). A wide range of factors has also been found to in?uence average costs including scale,intervention design,context,capacity,project age,inef?ciencies and prices (5?8, 10?12, 19, 30?33). In order to facilitate the comparisons between costs and scale of operation,the sampling procedure controls for epidemiology, intervention design and context as far as possible. Inevitably,as the sample is taken from an active programme, these factors vary across the interventions. For example, two of the 17 interventions provided STI services within their own clinics. Other interventions referred people for treatment and, except for three interventions, provided a subsidy to the provider. Although this may limit the compa - rability of the interventions,it re?ects the reality of scaling-up in which there will always be variation in the design of the intervention. The context of the interventions also varied. The inter - ventions examined took place in two different states and were funded by four different organizations. Despite these differ - ences, the analysis found that these contextual factors and intervention characteristics had no in?uence on unit costs (see Appendix 2 and Appendix 3) nor did the non-parametric tests allow us to reject the hypothesis that there is no relationship between prices and average costs (Appendix 3). It was not pos - sible to identify inef?ciencies associated with different levels of performance in quanti?able form. The analysis con?rms that scale is a key factor in in - ?uencing the unit cost, resulting in a U-shaped average cost curve. Due to the limitations of the data, the cost function is not derived from a production function but is descriptive. This makes it more dif?cult to identify the causes of change in average cost and to explain the relationship between costs and scale. Fig. 4 (a v ailable only on the w eb at http:// www.who.int/bulletin) looks at the relationship between cost st r uctu r e and c o v erage. Fig. 4 sh o ws that the pe r centage of costs spent at the funding agency-level falls as coverage increases, but no other trends are discernable, emphasizing the context-speci?c nature of costs and the need for further research into the economics of the design and implementation of HIV prevention services. The changing nature of the average cost has important implications for planning the resources needed for scaling-up interventions. Contrary to expectations that the high propor - tion of variable costs would lead to constant average costs and the resource estimation techniques that assume this, average costs fall and then rise again as coverage increases. Estimates of resource requirements that are based on a constant average cost would therefore signi?cantly underestimate or overestimate the total costs. The results of this study,derived from a unique set of data on the costs of HIV prevention services across multiple sites, highlight the importance of using scale-speci?c cost infor - mation in order to identify the optimal size of an intervention and to improve estimates of resource requirements. O Acknowledgements We thank Dr Kara Hanson and two anonymous reviewers for their invaluable comments, Professor V R Muraleedharan, Indian Institute of Technology (Madras) and Professor Charles Normand for their continued support, as well as all the participating NGOs and their funding agencies for their extensive cooperation. Funding: This research was funded by the Wellcome Trust, United Kingdom. Lorna Guinness is a Wellcome Trust Research Fellow at the London School of Hygiene and Tropical Medicine and also a member of the Health Economics and Financing Programme, which receives funds from the Department For International Development of the United Kingdom (DFID). Lilani Kumaranayake is a member of the Department for International Development of the United Kingdom-funded Tuberculosis and AIDS/STI Knowledge Programmes at the London School of Hygiene and Tropical Medicine. DFID supports policies,programmes and projects to promote inter - national development. The views and opinions expressed are those of the authors alone. Competing interests: none declared. Fig. 4. Relationship between cost structure and coverage of the interventions WHO 05.73 Median % of total cost Fixed personnel Input category High cost, low coverage 50 45 40 35 30 25 20 15 10 5 0 Mid-cost, low coverage Mid-cost, low coverage High cost, high coverage Building office costs Variable personnel Peer educators Agency Total personnel 754 Bulletin of the World Health Organization | October 2005, 83 (10) Research HIV prevention in India Lorna Guinness et al. Résumé Coûts des interventions visant à prévenir la transmission du VIH chez les travailleurs du sexe indiens : in?uence de l?échelle du projet Objectif Étudier l?impact de l?échelle d?un projet sur les coûts totaux et moyens de la prévention de la transmission du VIH en Inde. Méthodes Pour 17 interventions gérées par des organisations non gouvernementales et visant les professionnels du sexe du sud de l?Inde, on a recueilli des données relatives aux coûts et des mesures de l?échelle du projet [couverture et indicateurs du volume de services correspondant aux nombres de cas d?infections sexuellement transmissibles (IST) adressés, d?IST traitées, de préservatifs distribués et de contacts noués avec les groupes cibles]. La relation entre coûts totaux, coûts unitaires et échelle du projet a été analysée par des méthodes non paramétriques et des analyses par régression. Résultats La couverture des interventions allait de 250 à 2 008 professionnels du sexe. Les coûts annuels se situaient entre US $ 11 274 et US $ 52 793. Le coût médian par travailleur du sexe atteignait US $ 19,21 (plage de variation : US $ 10,00 à 51,00). Les variables d?échelle permettaient de justi?er plus de 50 % de la variation des coûts unitaires pour l?ensemble des mesures de coût unitaire, éxcepté le coût par contact. Les coûts totaux et les coûts unitaires sont reliés à l?échelle par une relation non linéaire. Conclusion Les coûts moyens varient avec l?échelle du projet. Les estimations des besoins en ressources se fondant sur un coût moyen constant pourraient donc conduire à une sous-estimation ou à une surestimation des coûts totaux. Les résultats de l?étude font ressortir l?importance pour la plani?cation d?une meilleure information sur les coûts dépendant de l?échelle du projet. Resumen La escala, ¿un factor importante? Costo de las intervenciones de prevención de la infección por VIH entre los profesionales del sexo en la India Objetivo Estudiar cómo in?uye la escala de un proyecto tanto en los costos totales como en los costos medios de la prevención de la infección por VIH en la India. M é t o d o s A p a r t i r d e 1 7 i n t e r v e n c i o n e s e m p r e n d i d a s p o r organizaciones no gubernamentales entre profesionales del sexo en el sur de la India, se reunieron datos sobre los costos económicos e indicadores de la escala de la intervención (cobertura y volumen de servicios para el número de casos de infecciones de transmisión sexual (ITS) remitidos, número de ITS tratadas, número de preservativos distribuidos y contactos habidos con los grupos destinatarios). La relación entre los costos totales, los costos unitarios y la escala se determinó mediante métodos no paramétricos y análisis de regresión. Resultados La cobertura varió entre 250 y 2 008 profesionales del sexo. Los costos anuales oscilaron entre US$ 11 274 y US$ 52 793. La mediana del costo por profesional del sexo alcanzado fue de US$ 19,21 (intervalo: US$ 10,00 - 51,00). Las variables indicativas de la escala explican más del 50% de la variación de los costos unitarios para todas las medidas del costo unitario, exceptuando el costo por contacto. Los costos totales y los costos unitarios están relacionados de manera no lineal con la escala. Conclusión Los costos medios varían con la escala del proyecto. Las estimaciones de las necesidades de recursos basadas en un costo medio constante tienden a subestimar o sobrestimar los costos totales. Los resultados destacan la importancia de mejorar la información sobre los costos en función de la escala a efectos de plani?cación. 755 Research Lorna Guinness et al. HIV prevention in India References 1. Schwartlander B, Stover J, Walker N, Bollinger L, Gutierrez JP, McGreevey W, et al. Resource needs for HIV/AIDS. Science 2001;292: 2434-6. 2. Commission on Macroeconomics and Health. Macroeconomics and health: investing in health for economic development. Geneva: World Health Organization; 2001. 3. UNAIDS. 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