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Modern HIV May Be Slightly Less Virulent, Laboratory Study Suggests.
John S. James, The Body, October 16, 2005.
A laboratory study comparing recent (2002-2003) vs. early (1986-1989) untreated HIV found that the recent virus reproduced somewhat less well, and appeared more sensitive to two antiretrovirals tested (3TC and TAK-779, a CCR5 antagonist no longer being developed as a drug). The authors suggested that "this 'attenuation' could be the consequence of serial bottlenecks during transmission and result in adaptation of HIV-1 to the human host.
